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XIAFLEX® Copay Assistance Program

If eligible, you'll pay $0 out of pocket for XIAFLEX®*

How much you pay for XIAFLEX® will depend on your health benefits or insurance coverage.

The XIAFLEX® Copay Assistance Program can cover up to $1200 of your out-of-pocket costs for each injection of XIAFLEX®.

To find out if you qualify, call 1-800-743-2382.

Most eligible patients with commercial insurance plans paid zero dollars out of pocket


Patients are eligible for assistance under this program if:

  • You are receiving or have received XIAFLEX® for the approved indication and in a manner consistent with the instructions for administration of XIAFLEX®
  • You are uninsured or have insurance that is not provided by Medicare, Medicare Prescription Drug Benefit plans, Medicare Advantage, Veterans Affairs (VA), Medicaid, or similar federal or state programs, and this program is not otherwise prohibited by law
  • You are 18 years of age or older
  • You have paid or are obligated to pay out-of-pocket costs for a prescription of XIAFLEX®

No other purchase is necessary to receive this offer.

For more information, call 1-800-743-2382.

  • 1. By accepting this offer, you agree to report the value received under this offer to any health insurer or other third party paying for any part of the XIAFLEX® prescription if you are required to do so by benefit terms, contract, or law.
  • 2. This offer is not valid for prescriptions reimbursed in whole or in part by Medicare, Medicare Prescription Drug Benefit plans, Medicare Advantage, VA, Medicaid, or similar federal or state programs, or where otherwise prohibited by law.
  • 3. By accepting this offer, you agree that Endo Pharmaceuticals Inc. or those working on its behalf may contact your doctor to verify information about treatment that is relevant to verifying your eligibility for this offer.
  • 4. This offer is only valid for doses of XIAFLEX® administered in the US.
  • 5. This offer is valid for the out-of-pocket cost for the dose of XIAFLEX® only. Offer is not valid for any other products or other out-of-pocket costs (for example, office visit charges, office visit copays, or injection/administration costs), even if those costs are associated with the administration of a dose of XIAFLEX®.
  • 6. This offer is valid only if you have not used this program within the last 30 days.
  • 7. The selling, purchasing, trading, or counterfeiting of this offer is prohibited.
  • 8. Endo Pharmaceuticals Inc. reserves the right to rescind, revoke, or amend this offer without notice.
  • 9. By participating, you understand and agree to comply with the terms and conditions of this offer as set forth above.

Based on analysis of over 4000 claims filed January 2015 through October 2015.

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Important Safety Information

Do not receive XIAFLEX® if you:
  • have been told by your healthcare provider that the Peyronie's plaque to be treated involves the "tube" that your urine passes through (urethra)
  • are allergic to collagenase clostridium histolyticum or any of the ingredients in XIAFLEX®, or to any other collagenase product. See the end of the Medication Guide for a complete list of ingredients in XIAFLEX®

XIAFLEX® can cause serious side effects, including:

  1. Penile fracture (corporal rupture) or other serious injury to the penis. Receiving an injection of XIAFLEX® may cause damage to the tubes in your penis called the corpora. After treatment with XIAFLEX®, one of these tubes may break during an erection. This is called a corporal rupture or penile fracture. This could require surgery to fix the damaged area. Damage to your penis might not get better after a corporal rupture.
    • After treatment with XIAFLEX®, blood vessels in your penis may also break, causing blood to collect under the skin (hematoma). This could require a procedure to drain the blood from under the skin

    Symptoms of corporal rupture or other serious injury to your penis may include:

    • a popping sound or sensation in an erect penis
    • sudden loss of the ability to maintain an erection
    • pain in your penis
    • purple bruising and swelling of your penis
    • difficulty urinating or blood in the urine

    Call your healthcare provider right away if you have any of the symptoms of corporal rupture or serious injury to the penis listed above.

    Do not have sex or any other sexual activity between the first and second injections of a treatment cycle.

    Do not have sex or have any other sexual activity for at least 4 weeks after the second injection of a treatment cycle with XIAFLEX® and after any pain and swelling has gone away.

    XIAFLEX® for the treatment of Peyronie's disease is only available through a restricted program called the XIAFLEX® Risk Evaluation and Mitigation Strategy (REMS) Program. For more information about the XIAFLEX® REMS Program, go to www.XIAFLEXREMS.com or call 1‑877‑942‑3539.

  2. Hypersensitivity reactions, including anaphylaxis. Severe allergic reactions can happen in people who receive XIAFLEX®, because it contains foreign proteins.

    Call your healthcare provider right away if you have any of these symptoms of an allergic reaction after an injection of XIAFLEX®:

    • hives
    • swollen face
    • breathing trouble
    • chest pain
    • low blood pressure
    • dizziness or fainting

Before receiving XIAFLEX®, tell your healthcare provider if you have had an allergic reaction to a previous XIAFLEX® injection, or have a bleeding problem or any other medical conditions. Tell your healthcare provider about all the medicines you take, including prescription and non‑prescription medicines, vitamins, and herbal supplements. Using XIAFLEX® with certain other medicines can cause serious side effects. Especially tell your healthcare provider if you take medicines to thin your blood (anticoagulants). If you are told to stop taking a blood thinner before your XIAFLEX® injection, your healthcare provider should tell you when to restart the blood thinner. Ask your healthcare provider or pharmacist for a list of these medicines if you are unsure.

What should I avoid while receiving XIAFLEX®?
Avoid situations that may cause you to strain your stomach (abdominal) muscles, such as straining during bowel movements.

Do not use a vacuum erection device during your treatment with XIAFLEX®.

XIAFLEX® can cause serious side effects, including increased chance of bleeding. Bleeding or bruising at the injection site can happen in people who receive XIAFLEX®. Talk to your healthcare provider if you have a problem with your blood clotting. XIAFLEX® may not be right for you.

The most common side effects with XIAFLEX® for the treatment of Peyronie's disease include:

  • a small collection of blood under the skin at the injection site (hematoma)
  • swelling at the injection site or along your penis
  • pain or tenderness at the injection site, along your penis and above your penis
  • penis bruising
  • itching of your penis or scrotum (genitals)
  • painful erection
  • erection problems (erectile dysfunction)
  • changes in the color of the skin of your penis
  • blisters at the injection site
  • pain with sex
  • a lump at the injection site (nodule)

Tell your healthcare provider if you have any side effect that bothers you or does not go away.

These are not all of the possible side effects with XIAFLEX®. For more information, ask your healthcare provider or pharmacist.

What is XIAFLEX®?

XIAFLEX® is a prescription medicine used to treat adult men with Peyronie's disease who have a "plaque" that can be felt and a curve in their penis greater than 30 degrees when treatment is started.

It is not known if XIAFLEX® is safe and effective in children under the age of 18.

Please see the full Prescribing Information, including Boxed Warning and Medication Guide.