- Prescribing Information
- Medication Guide
- Important Safety Information
- For Healthcare Professionals
Treating your curved erection due to PD with XIAFLEX®
There are 2 equally important parts of treatment with XIAFLEX
If you and your urologist decide that XIAFLEX (collagenase clostridium histolyticum) is right for you, you'll partner up to do these 2 things:
-
A series of in-office injections with XIAFLEX To help weaken and break down the Peyronie's plaque (a bump of scar tissue under the skin of the penis) that's causing your curved erection, your urologist or a trained urology healthcare professional (HCP) will inject XIAFLEX directly into the plaque that is causing your penis to curve. -
Gentle stretching and straightening activities, also known as penile modeling To help reduce the curve in your erection and straighten the shaft of your penis, your HCP will stretch and straighten your penisin-office to elongate your treated plaque and you'll perform similar activities at home.
Every part of treatment is important to get the best possible results.
This is the treatment schedule for XIAFLEX injections and penile modeling
It took time for the complex plaque that's causing your curved erection to form, and it'll take time to break it down.
XIAFLEX works to help gradually break down your plaque over 1 to 4 treatment cycles, with about 6 weeks between each treatment cycle.
You will book 3 separate office visits for each treatment cycle
Visit 1
Injection 1
Wait 1–3 days
Visit 2
Injection 2
Wait 1–3 days
Visit 3
HCP will stretch & straighten
your penis
At Home
You stretch & straighten
About 6 weeks
Do not have sex or other sexual activity during these times:
- Between the first and second injections of each treatment cycle
- For at least 4 weeks after the second injection of each treatment cycle, and after any pain and swelling have gone away
- Avoid abdominal straining associated with situations, such as straining during bowel movements
Your HCP will let you know how many treatment cycles are right for you. The number of cycles needed to break down your Peyronie's plaque depends on a variety of factors, like:
- The degree of your curved erection
- The size and density of your plaque
- Staying on schedule with your injections
- Doing your daily gentle stretching and straightening activities between each treatment cycle
Be sure to schedule all of your appointments for XIAFLEX when you first start treatment.
In clinical trials, 80% of men treated with XIAFLEX received all 4 treatment cycles.
Penis stretching and straightening activities after each treatment cycle with XIAFLEX
In addition to staying on track with HCP appointments for XIAFLEX, you have a very important job to do at home.
For 6 weeks after each treatment cycle with XIAFLEX, you'll need to take a few minutes each day to do penile modeling—gentle stretching and straightening activities for your penis. When paired with injections of XIAFLEX, these activities help to break down your Peyronie's plaque and help reduce the curve in your erection.
Your HCP will show you how to do these activities, but here's a helpful how-to guide that you can refer back to at home.
Penis stretching activity
Gently stretch your penis 3 times each day when it is not hard (erect).
With 1 hand, hold the tip of your penis with your fingers. With your other hand, hold the base of your penis
Gently pull your penis away from your body to its full length and hold the stretch
Let go of the tip of your penis and let your penis return to
Remember:
- Only stretch your penis if it is not hard
- Try to spread these 3 stretching sessions out over the course of your day
Penis straightening activity
Gently straighten your penis 1 time each day when it is erect unrelated to sexual activity (spontaneous erection).
With 1 hand, hold your erect penis.
With your other hand, gently bend your penis in the opposite direction of the curve.
Hold the penis in this more straightened position for 30 seconds, then let go.
Remember:
- Only straighten your penis if you have an erection that happens without any sexual activity
- Bending your penis should not cause any pain or discomfort
Treatment with XIAFLEX is a partnership between you and your urologist.
What to expect during and after treatment with XIAFLEX
Important things to remember during treatment
As with any medicine, there are important things to do and not do during treatment with XIAFLEX.
Be sure to follow these instructions throughout your treatment:
Your penis may be wrapped with a bandage after each injection Your HCP will tell you when to take the bandage off
Avoid situations that may cause you to strain your stomach (abdominal) muscles such as straining during bowel movements
Do not use a vacuum erection device during your treatment with XIAFLEX
Avoid sexual activity during these times Between the first and second injections of each treatment cycle and for at least 4 weeks after the second injection of each treatment cycle, and after any pain and swelling have gone away
You may experience side effects after your injections
It's common to have these reactions at or near the site where XIAFLEX was injected into your penis:
- Swelling
- Bruising
- Pain
These are not all of the possible side effects with XIAFLEX. For more information, ask your HCP.
Call your HCP right away if you have any of the following symptoms of corporal rupture or serious injury to the penis:
- A popping sound or sensation in an erect penis
- Sudden loss of the ability to maintain an erection
- Severe pain in your penis
- Severe purple bruising and swelling of your penis
- Difficulty urinating or blood in the urine
Tell your healthcare provider right away if you have sudden back pain, chest pain, or hard time walking after an injection.
If you have any other questions about what to expect during treatment with XIAFLEX, it's a good idea to ask your HCP.
