- Prescribing Information
- Medication Guide
- Important Safety Information
- For Healthcare Professionals
Treating your curved erection with XIAFLEX®
There are 2 equally important parts of treatment with XIAFLEX®
If you and your urologist decide that
Every part of treatment is important to get the best possible results.
This is the treatment schedule for XIAFLEX® injections and penile modeling
It took time for the complex plaque that's causing your curved erection to form, and it'll take time to break it down.
You will book 3 separate office visits for each treatment cycle
Visit 1
Injection 1
Wait 1–3 days
Visit 2
Injection 2
Wait 1–3 days
Visit 3
HCP will stretch & straighten
your penis
At Home
You stretch & straighten
About 6 weeks
Avoid sexual activity during these times:
- Between the first and second injections of each treatment cycle
- For at least 4 weeks after the second injection of each treatment cycle, and after any pain and swelling have gone away
Your HCP will let you know how many treatment cycles are right for you. The number of cycles needed to break down your Peyronie's plaque depends on a variety of factors, like:
- The degree of your curved erection
- The size and density of your plaque
- Staying on schedule with your injections
- Doing your daily stretching and straightening activities between each treatment cycle
Be sure to schedule all of your appointments for
In clinical trials, 80% of men treated with


Penis stretching and straightening activities after each treatment cycle with XIAFLEX®
In addition to staying on track with HCP appointments for
For 6 weeks after each treatment cycle with
Your HCP will show you how to do these activities, but here's a helpful how-to guide that you can refer back to at home.
Penis stretching activity
Gently stretch your penis 3 times each day when it is not hard (erect).



With 1 hand, hold the tip of your penis with your fingers. With your other hand, hold the base of your penis
Gently pull your penis away from your body to its full length and hold the stretch
Let go of the tip of your penis and let your penis return to
Remember:
- Only stretch your penis if it is not hard
- Try to spread these 3 stretching sessions out over the course of your day
Penis straightening activity
Gently straighten your penis 1 time each day when it is erect unrelated to sexual activity (spontaneous erection).



With 1 hand, hold your erect penis.
With your other hand, gently bend your penis in the opposite direction of the curve.
Hold the penis in this more straightened position for 30 seconds, then let go.
Remember:
- Only straighten your penis if you have an erection that happens without any sexual activity
- Bending your penis should not cause any pain or discomfort
Treatment with
What to expect during and after treatment with XIAFLEX®
Important things to remember during treatment
As with any medicine, there are important things to do and not do during treatment with
Be sure to follow these instructions throughout your treatment:
You may experience side effects after your injections
It's common to have these reactions at or near the site where
- Swelling
- Bruising
- Pain
These are not all of the possible side effects with
Call your HCP right away if you have any of the following symptoms of corporal rupture or serious injury to the penis:
- A popping sound or sensation in an erect penis
- Sudden loss of the ability to maintain an erection
- Severe pain in your penis
- Severe purple bruising and swelling of your penis
- Difficulty urinating or blood in the urine
If you have any other questions about what to expect during treatment with