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For adult men with peyronie's disease who have a "plaque" that can be felt and a curve in their penis greater than 30 degrees when treatment is started

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man with peyronie's disease
man with peyronie's disease
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You may find what you’re looking for here, but remember to always talk to your urologist about Peyronie’s disease and your treatment options too.

Frequently asked questions about Peyronie's disease (PD)

Peyronie’s disease is a condition involving a buildup of scar tissue that develops under the skin of the penis and causes an abnormal bend with a bump in the erection that you may or may not feel.
There is no guarantee that a bend in an erection will be fully cured, but you and your urologist can talk about treatment options that might be right for you.
You can find the full symptoms of Peyronie’s disease here.
A bend caused by a Peyronie’s plaque is unlikely to get better on its own.
The exact cause of Peyronie’s disease is unknown. There are multiple reasons why you might have PD, like from an injury, genetics, or age. What's important is that you visit a urologist to have your symptoms diagnosed and discuss treatment.
Every man's penis is different. Some bends are normal, and some are not. You could have Peyronie's disease with a bend in your erection ranging anywhere from 15 to 90 degrees.

Frequently asked questions about XIAFLEX®

When paired with daily penile exercises, there are enzymes in XIAFLEX that work together and are thought to gradually help break down the plaque that's causing a bend in your erection.
A 24 week course of XIAFLEX includes 4 treatment cycles. You may need between 1 to 4 treatment cycles with about 6 weeks between each cycle. You and your doctor will discuss how many treatment cycles are right for you.
When paired with gentle stretching and straightening of the penis, XIAFLEX is proven to help gradually reduce erectile curvature. Individual results will vary.
Recovery time after treatment with XIAFLEX varies for each patient. Be sure to discuss any questions or concerns you may have about your recovery with your urologist.
In clinical studies for Peyronie's disease, XIAFLEX was not associated with shortening of penis length.
You cannot have sex or engage in any other sexual activity between the first and second injections of each treatment cycle and for at least 4 weeks after the second injection of each treatment cycle, and after any pain and swelling have gone away. Your healthcare provider will tell you when you can resume sexual activity after each treatment cycle.
It's common to have these reactions at or near the site where XIAFLEX was injected into your penis:
  • Swelling
  • Bruising
  • Pain or tenderness
  • Itching
  • Painful erection
  • Hematoma (a small collection of blood under the skin)
  • Blisters
  • Nodule (lump)
  • Erection problems
  • Pain during sex
  • Discoloration of penis skin
These are not all the possible side effects with XIAFLEX. For more information, ask your healthcare provider.

If severe pain persists, contact your healthcare provider as soon as possible.

XIAFLEX is an FDA-approved injectable treatment for appropriate men with Peyronie's disease.
XIAFLEX should be injected into the plaque by a healthcare provider who is trained and experienced in treating adult men with Peyronie’s disease. Not all urologists have this training. Find someone who does near you.
For some men, XIAFLEX may be covered by insurance, but for others it may not be. For those men, there is a copay assistance program. To find out if you qualify, see eligibility criteria here, or call 1-800-743-2382.
Patients receiving XIAFLEX through a specialty pharmacy will receive a phone call from CVS Specialty Pharmacy. It is important to answer this call to confirm your prescription, so that XIAFLEX may be shipped to your doctor's office. Please see our informational video about this process here.

Do not receive XIAFLEX if:

  • the Peyronie's plaque to be treated involves the "tube" that your urine passes through (urethra).
  • you are allergic to collagenase clostridium histolyticum or any of the ingredients in XIAFLEX, or to any other collagenase product. See the end of the Medication Guide for a complete list of ingredients in XIAFLEX.

What is XIAFLEX®?

XIAFLEX is a prescription medicine used to treat adult men with Peyronie's disease who have a "plaque" that can be felt and a curve in their penis greater than 30 degrees when treatment is started.

It is not known if XIAFLEX is safe and effective in children under the age of 18.

Important Safety Information

Do not receive XIAFLEX if:

  • the Peyronie's plaque to be treated involves the "tube" that your urine passes through (urethra).
  • you are allergic to collagenase clostridium histolyticum or any of the ingredients in XIAFLEX, or to any other collagenase product. See the end of the Medication Guide for a complete list of ingredients in XIAFLEX.

XIAFLEX can cause serious side effects, including:

  1. Penile fracture (corporal rupture) or other serious injury to the penis. Receiving an injection of XIAFLEX may cause damage to the tubes in your penis called the corpora. After treatment with XIAFLEX, one of these tubes may break during an erection. This is called a corporal rupture or penile fracture. This could require surgery to fix the damaged area. Damage to your penis might not get better after a corporal rupture.

    • After treatment with XIAFLEX, blood vessels in your penis may also break, causing blood to collect under the skin (hematoma). This could require a procedure to drain the blood from under the skin. If a hematoma appears, skin and soft tissue necrosis (death of skin cells) may develop in that area, which could require surgery.

    Symptoms of corporal rupture or other serious injury to your penis may include:

    • a popping sound or sensation in an erect penis
    • sudden loss of the ability to maintain an erection
    • pain in your penis
    • purple bruising and swelling of your penis
    • difficulty urinating or blood in the urine

    Call your healthcare provider right away if you have any of the symptoms of corporal rupture or serious injury to the penis listed above.

    Do not have sex or any other sexual activity between the first and second injections of a treatment cycle.

    Do not have sex or have any other sexual activity for at least 4 weeks after the second injection of a treatment cycle with XIAFLEX and after any pain and swelling has gone away.

    XIAFLEX for the treatment of Peyronie's disease is only available through a restricted program called the XIAFLEX Risk Evaluation and Mitigation Strategy (REMS) Program.

  2. Hypersensitivity reactions, including anaphylaxis. Severe allergic reactions can happen in people who receive XIAFLEX, because it contains foreign proteins.

    Call your healthcare provider right away if you have any of these symptoms of an allergic reaction after an injection of XIAFLEX:

    • hives
    • swollen face
    • breathing trouble
    • chest pain
    • low blood pressure
    • dizziness or fainting
  3. Back pain reactions. After receiving an injection of XIAFLEX for Peyronie’s disease, you may suddenly feel back pain, including severe lower back pain moving to your legs, feet, chest and arms. The back pain may also include spasms and make it hard to walk. These symptoms usually go away in 15 minutes or less, but may last longer.
    Tell your healthcare provider right away if you have sudden back pain, chest pain, or hard time walking after an injection.

  4. Fainting. Fainting (passing out) or near fainting can happen in men who receive XIAFLEX, especially if they have severe penile pain.
    If you have dizziness or feel faint after receiving XIAFLEX, lie down until the symptoms go away.

Before receiving XIAFLEX, tell your healthcare provider if you have had an allergic reaction to a previous XIAFLEX injection, have a bleeding problem, received XIAFLEX for another condition, or any other medical conditions. Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Using XIAFLEX with certain other medicines can cause serious side effects. Especially tell your healthcare provider if you take medicines to thin your blood (anticoagulants). If you are told to stop taking a blood thinner before your XIAFLEX injection, your healthcare provider should tell you when to restart the blood thinner. Ask your healthcare provider or pharmacist for a list of these medicines, if you are not sure.

What should I avoid while receiving XIAFLEX?
Avoid situations that may cause you to strain your stomach (abdominal) muscles, such as straining during bowel movements.

Do not use a vacuum erection device during your treatment with XIAFLEX.

XIAFLEX can cause serious side effects, including increased chance of bleeding. Bleeding or bruising at the injection site can happen in people who receive XIAFLEX. Talk to your healthcare provider if you have a problem with your blood clotting. XIAFLEX may not be right for you.

The most common side effects with XIAFLEX for the treatment of Peyronie's disease include:

  • a small collection of blood under the skin at the injection site (hematoma)
  • swelling at the injection site or along your penis
  • pain or tenderness at the injection site, along your penis and above your penis
  • penis bruising
  • itching of your penis or scrotum (genitals)
  • painful erection
  • erection problems (erectile dysfunction)
  • changes in the color of the skin of your penis
  • blisters at the injection site
  • pain with sex
  • a lump at the injection site (nodule)

Tell your healthcare provider if you have any side effect that bothers you or does not go away.

These are not all of the possible side effects with XIAFLEX. For more information, ask your healthcare provider or pharmacist. You may report side effects to FDA at 1-800-FDA-1088.

Click for full Prescribing Information, including BOXED WARNING and Medication Guide.

Please see full Prescribing Information, including BOXED WARNING and Medication Guide.

What is XIAFLEX®?

XIAFLEX is a prescription medicine used to treat adult men with Peyronie's disease who have a "plaque" that can be felt and a curve in their penis greater than 30 degrees when treatment is started. It is not known if XIAFLEX is safe and effective in children under the age of 18.

IMPORTANT SAFETY INFORMATION

Do not receive XIAFLEX if the Peyronie's plaque to be treated involves the "tube" that your urine passes through (urethra). You are allergic to collagenase clostridium histolyticum or any of the ingredients in XIAFLEX, or to any other collagenase product. See the end of the Medication Guide for a complete list of ingredients in XIAFLEX.