- Prescribing Information
- Medication Guide
- Important Safety Information
- For Healthcare Professionals
Get the facts about XIAFLEX® for Peyronie's disease
What is XIAFLEX?
Treatment involves a series of injections given by trained urologists in their office. When paired with gentle stretching and straightening of the penis, XIAFLEX is proven to help reduce erectile curvature.
Due to the symptoms of Peyronie's disease and the way XIAFLEX has been studied, you need to have the following 2 symptoms in order to start treatment with XIAFLEX:
A PEYRONIE'S PLAQUE
A bump of scar tissue under the skin of the penis that can be felt
A CURVED ERECTION
Bent at least 30 degrees at the start of treatment
Don't worry about figuring out these things yourself. A urologist can discuss what your treatment options are depending on your degree of curvature and check for a Peyronie's plaque.
More than 250,000 doses of XIAFLEX
have been distributed to trained physicians who treat Peyronie's disease, since FDA approval.
Actor portrayals.
See why nonsurgical treatment with XIAFLEX was right for Jerry
Jerry & Dayna's story
See how Jerry opened up to his wife about Peyronie's disease and how they researched options together. Jerry, an actual patient, and his wife Dayna were compensated for their time.
Jerry & Dayna's story
Learn how Jerry and his wife dealt with Peyronie's disease together.
XIAFLEX is proven to help reduce erectile curvature
Before and after results from clinical trials show that XIAFLEX works
Two large clinical trials evaluated how XIAFLEX works in more than 500 men. Men received either up to 4 treatment cycles of XIAFLEX with gentle penile stretching and straightening, or placebo injection with gentle penile stretching and straightening, and then were observed to:
- Measure the percentage reduction in erectile curvature from the beginning of the study to Week 52
- Measure the change in Bother domain score at the beginning and end (Week 52). The Bother domain score is a total score from answers about the following items:
- Concern about how their erection looks and about erection pain
- Impact of Peyronie’s disease on frequency of intercourse
- Impact of Peyronie’s disease on intercourse
- Evaluate the safety of using XIAFLEX
In both trials, men were divided into 2 groups:
- Over an 18-week period, one group received XIAFLEX injections and did gentle penis stretching and straightening
- Over an 18-week period, the other group received placebo injections (no medicine) and did gentle penis stretching and straightening
Men in both groups were then observed without receiving any treatment until Week 52.
Results: Erectile curvature improved
Men who received XIAFLEX and performed daily gentle penile stretching and straightening activities had an average change in their erectile curvature with a treatment difference of 17% in study 1 and 11% in study 2 from the beginning of the studies to Week 52 compared to men who were treated with placebo (no medicine).
Results: Self-reported improvement in Bother Domain Score
Men who received XIAFLEX and performed gentle penile stretching and straightening activities reported improvement in Bother from the beginning of the study to Week 52 compared to placebo.
In clinical studies for Peyronie's disease, XIAFLEX was not associated with shortening of penis length.
Here's how XIAFLEX breaks down a Peyronie's plaque
There are enzymes in XIAFLEX that work together to gradually weaken and break down the plaque that's causing your erection to curve.
Step 1: Attaches to the complex fibers within the Peyronie's plaque
Step 2: Unwinds the complex fibers that make up the plaque
Step 3: Breaks down the bonds that hold the plaque together
Once the plaque in your penis breaks down, the result is less curvature.
XIAFLEX is designed to target the complex fibers within the Peyronie’s plaque that make your penis curve when it is erect. Injecting XIAFLEX into other tissues of the penis that are made up of a similar material may result in damage to those tissues and injury to the penis. To help ensure XIAFLEX only breaks down the plaque, urologists must be specially certified to inject XIAFLEX directly into it.
~90% of eligible patients paid
with the XIAFLEX
See eligibility requirements and terms and conditions
† Most eligible patients with commercial insurance plans paid $0 copay for XIAFLEX. Based on analysis of claims filed November 2017 through April 2020.
