Find A Urologist
Menu
A prescription medicine used to treat adult men with Peyronie’s disease who have a “plaque” that can be felt and a curve in their penis greater than 30 degrees when treatment is started
A prescription medicine used to treat adult men with Peyronie’s disease who have a “plaque” that can be felt and a curve in their penis greater than 30 degrees when treatment is started
Search icon
Menu
Find A Urologist

Get the facts about XIAFLEX® for Peyronie's disease

What is XIAFLEX®?

XIAFLEX® (collagenase clostridium histolyticum) is the only nonsurgical treatment option for appropriate adult men with Peyronie's disease approved by the Food and Drug Administration (FDA).

Treatment involves a series of injections given by trained urologists in their office. When paired with gentle stretching and straightening of the penis, XIAFLEX® is proven to help reduce erectile curvature.

Due to the symptoms of Peyronie's disease and the way XIAFLEX® has been studied, you need to have the following 2 symptoms in order to start treatment with XIAFLEX®:

A PEYRONIE'S PLAQUE
A bump of scar tissue under the skin of the penis that can be felt

A CURVED ERECTION
Bent at least 30 degrees at the start of treatment

A curved erection bent 30 degrees with a bump of scar tissue under the skin of a penis

Don't worry about figuring out these things yourself. A urologist can discuss what your treatment options are depending on your degree of curvature and check for a Peyronie's plaque.

Find a urologist to get diagnosed

More than 152,000 injections of XIAFLEX®

have been given to men with Peyronie's disease.*

Actor portrayals.

Group of men portraying the number of men that have been treated for Peyronie's disease with XIAFLEX® Group of men portraying the number of men that have been treated for Peyronie's disease with XIAFLEX®

*Injections performed are estimated based on the number of vials sold between January 2014 and October 2018.

See why nonsurgical treatment with XIAFLEX® was right for Jerry

Jerry & Dayna's story

See how Jerry opened up to his wife about Peyronie's disease and how they researched options together. Jerry, an actual patient, and his wife Dayna were compensated for their time.

XIAFLEX® is proven to help reduce erectile curvature

Before and after results from clinical trials show that XIAFLEX® works

Two large clinical trials evaluated how XIAFLEX® works in more than 500 men. Men received either up to 4 treatment cycles of XIAFLEX® with gentle penile stretching and straightening, or placebo injection with gentle penile stretching and straightening, and then were observed to:

  • Measure the percentage reduction in erectile curvature from the beginning of the study to Week 52
  • Measure the change in Bother domain score at the beginning and end (Week 52). The Bother domain score is a total score from answers about the following items:
    • Concern about how their erection looks and about erection pain
    • Impact of Peyronie’s disease on frequency of intercourse
    • Impact of Peyronie’s disease on intercourse
  • Evaluate the safety of using XIAFLEX®

In both trials, men were divided into 2 groups:

  • Over an 18-week period, one group received XIAFLEX® injections and did gentle penis stretching and straightening
  • Over an 18-week period, the other group received placebo injections (no medicine) and did gentle penis stretching and straightening

Men in both groups were then observed without receiving any treatment until Week 52.

Results: Erectile curvature improved

Men who received XIAFLEX® and performed gentle penile stretching and straightening activities had an average change in their erectile curvature of 33% to 35% from the beginning of the study to Week 52, compared with 18% to 22% in men who had placebo injection (no medicine) with gentle penile stretching and straightening.

XIAFLEX® before and after photo of a patient's penis, showing an erectile curvature before treatment XIAFLEX® before and after photo of a patient's penis, showing an erectile curvature before treatment XIAFLEX® before and after photo of a patient's penis after treatment XIAFLEX® before and after photo of a patient's penis after treatment

Results: Self-reported improvement in Bother Domain Score

Men who received XIAFLEX® and performed gentle penile stretching and straightening activities reported significant reductions on average of 33% to 35% compared to placebo injection (no medicine) at 18% to 22% from the beginning of the study to Week 52.

In clinical studies for Peyronie's disease, XIAFLEX® was not associated with shortening of penis length.

Here's how XIAFLEX® breaks down a Peyronie's plaque

There are enzymes in XIAFLEX® that work together to gradually weaken and break down the plaque that's causing your erection to curve.

XIAFLEX® treats Peyronie's disease by attaching to the Peyronie’s plaque XIAFLEX® treats Peyronie's disease by attaching to the Peyronie’s plaque

Step 1: Attaches to the complex fibers within the Peyronie's plaque

XIAFLEX® loosens complex fibers that make up Peyronie’s plaque XIAFLEX® loosens complex fibers that make up Peyronie’s plaque

Step 2: Unwinds the complex fibers that make up the plaque

XIAFLEX® breaks down bonds that hold Peyronie’s plaque together XIAFLEX® breaks down bonds that hold Peyronie’s plaque together

Step 3: Breaks down the bonds that hold the plaque together

Once the plaque in your penis breaks down, the result is less curvature.

XIAFLEX® is designed to target the complex fibers within the Peyronie’s plaque that make your penis curve when it is erect. Injecting XIAFLEX® into other tissues of the penis that are made up of a similar material may result in damage to those tissues and injury to the penis. To help ensure XIAFLEX® only breaks down the plaque, urologists must be specially certified to inject XIAFLEX® directly into it.

More than 95% of patients paid $0 out of pocket

with the XIAFLEX® Copay Assistance Program.

See eligibility requirements and terms and conditions

Get the details on getting treated
View allView less
Important Safety Information for XIAFLEX® (collagenase clostridium histolyticum)

Do not receive XIAFLEX® if you:

  • have been told by your healthcare provider that the Peyronie's plaque to be treated involves the "tube" that your urine passes through (urethra);
  • are allergic to collagenase clostridium histolyticum or any of the ingredients in XIAFLEX®, or to any other collagenase product. See the end of the Medication Guide for a complete list of ingredients in XIAFLEX®.

XIAFLEX® can cause serious side effects, including:

  1. Penile fracture (corporal rupture) or other serious injury to the penis. Receiving an injection of XIAFLEX® may cause damage to the tubes in your penis called the corpora. After treatment with XIAFLEX®, one of these tubes may break during an erection. This is called a corporal rupture or penile fracture. This could require surgery to fix the damaged area. Damage to your penis might not get better after a corporal rupture.
    • After treatment with XIAFLEX®, blood vessels in your penis may also break, causing blood to collect under the skin (hematoma). This could require a procedure to drain the blood from under the skin

    Symptoms of corporal rupture or other serious injury to your penis may include:

    • a popping sound or sensation in an erect penis
    • sudden loss of the ability to maintain an erection
    • pain in your penis
    • purple bruising and swelling of your penis
    • difficulty urinating or blood in the urine

    Call your healthcare provider right away if you have any of the symptoms of corporal rupture or serious injury to the penis listed above.

    Do not have sex or any other sexual activity between the first and second injections of a treatment cycle.

    Do not have sex or have any other sexual activity for at least 4 weeks after the second injection of a treatment cycle with XIAFLEX® and after any pain and swelling have gone away.

    XIAFLEX® for the treatment of Peyronie's disease is only available through a restricted program called the XIAFLEX® Risk Evaluation and Mitigation Strategy (REMS) Program. For more information about the XIAFLEX® REMS Program, go to www.XIAFLEXREMS.com or call 1‑877‑313‑1235.

  2. Hypersensitivity reactions, including anaphylaxis. Severe allergic reactions can happen in people who receive XIAFLEX®, because it contains foreign proteins.

    Call your healthcare provider right away if you have any of these symptoms of an allergic reaction after an injection of XIAFLEX®:

    • hives
    • swollen face
    • breathing trouble
    • chest pain
    • low blood pressure
    • dizziness or fainting

Before receiving XIAFLEX®, tell your healthcare provider if you have had an allergic reaction to a previous XIAFLEX® injection, or have a bleeding problem or any other medical conditions. Tell your healthcare provider about all the medicines you take, including prescription and non‑prescription medicines, vitamins, and herbal supplements. Using XIAFLEX® with certain other medicines can cause serious side effects. Especially tell your healthcare provider if you take medicines to thin your blood (anticoagulants). If you are told to stop taking a blood thinner before your XIAFLEX® injection, your healthcare provider should tell you when to restart the blood thinner. Ask your healthcare provider or pharmacist for a list of these medicines if you are unsure.

What should I avoid while receiving XIAFLEX®?
Avoid situations that may cause you to strain your stomach (abdominal) muscles, such as straining during bowel movements.

Do not use a vacuum erection device during your treatment with XIAFLEX®.

XIAFLEX® can cause serious side effects, including increased chance of bleeding. Bleeding or bruising at the injection site can happen in people who receive XIAFLEX®. Talk to your healthcare provider if you have a problem with your blood clotting. XIAFLEX® may not be right for you.

The most common side effects with XIAFLEX® for the treatment of Peyronie's disease include:

  • a small collection of blood under the skin at the injection site (hematoma)
  • swelling at the injection site or along your penis
  • pain or tenderness at the injection site, along your penis and above your penis
  • penis bruising
  • itching of your penis or scrotum (genitals)
  • painful erection
  • erection problems (erectile dysfunction)
  • changes in the color of the skin of your penis
  • blisters at the injection site
  • pain with sex
  • a lump at the injection site (nodule)

Tell your healthcare provider if you have any side effect that bothers you or does not go away.

These are not all of the possible side effects with XIAFLEX®. For more information, ask your healthcare provider or pharmacist.

What is XIAFLEX®?

XIAFLEX® is a prescription medicine used to treat adult men with Peyronie's disease who have a "plaque" that can be felt and a curve in their penis greater than 30 degrees when treatment is started.

It is not known if XIAFLEX® is safe and effective in children under the age of 18.

Please see the full Prescribing Information, including Boxed Warning and Medication Guide.