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What is Peyronie's disease?

Peyronie’s (pronounced “Pay-ROH-neez”) disease is the development of scar tissue, also known as a Peyronie’s plaque, under the skin of the penis that causes a curved erection.

An illustration highlighting the location of Peyronie's plaque on a penis

You may notice that the plaque that may be causing your curved erection feels firm, like a lump or bump. Or you may not even realize you have a plaque.

While the exact cause of Peyronie’s disease is not known, the plaque is thought to result from:

  • An injury or repeated trauma to the penis, which may occur during sexual activity
  • Genetic factors

Peyronie's disease is unlikely to go away on its own and may get worse over time. So if you have any of these penile symptoms, it's important to speak to a urologist to ask if you could have Peyronie's disease and find out about treatment options:

  • A curved erection, with or without pain
  • A lump or bump on your penis

Peyronie’s disease is more common than you might think

You're not alone. Thousands of men in the US may also have Peyronie's disease.

Because many men are too embarrassed to seek help for penile symptoms associated with Peyronie's disease, they often go undiagnosed.

*Based on a survey of more than 11,000 adult men with diagnosed Peyronie's disease in the US, a history of seeking care for the disease, or having related symptoms.

Peyronie's disease is different than erectile dysfunction

Some men who have Peyronie's disease may think that it's erectile dysfunction. Some big differences to look for are a lump or bump and a curve in your erection. If you have these symptoms, you could actually have Peyronie's disease.

While it is possible to have both erectile dysfunction and Peyronie's disease, these conditions each require their own separate diagnosis and treatment. Be sure to tell your healthcare professional (HCP) about all of your symptoms so they can help you figure out what's really going on.

What patients are saying

See what real guys with Peyronie's disease have to say about it

  • Ed

    "If you have Peyronie's disease, you're not alone. You don't have to be alone in this. You should talk to your urologist, you should find out what your options are, and take charge of it."

  • Jerry

    "You should do your research, discuss the options with your partner, make an appointment and go visit your urologist, ask about the various treatment options, and decide what's best for you."

  • Del

    "Find a urologist that you're comfortable with and who's experienced. And if they do diagnose you, take the time to understand your options. And go ahead. It's worth your patience."

"It's so personal...it's something physically wrong with you. I constantly felt like I had this diseased secret that I could not tell anybody." – Justin

"The first thing I noticed was the visible change. It was the curvature and that was where I was kind of in denial." – John

"You've got to learn what Peyronie's disease is, what the treatments are, who's the best to treat it. Education, education." – Jack

Patient video: Ed's story

Learn more about their experiences with Peyronie's disease

What to ask your HCP

Ask a urologist about your erectile curvature. It could be Peyronie's disease.

Whether or not you see a primary care provider first, you may need to talk to a urologist about your penile symptoms. Urologists specialize in the treatment of male urological conditions, including Peyronie's disease.

You may feel uncomfortable discussing erectile curvature with a urologist. Rest assured that urologists are used to talking about these kinds of things and are familiar with this condition, which could be Peyronie's disease.

Here are a few questions to get the conversation started:

  • Is my erectile curvature Peyronie's disease?
  • Is my curve 30 degrees or more?
  • Do I have a lump or bump (a plaque) that can be felt?

Be sure to also talk about if your symptoms bother you.


If you're diagnosed with Peyronie's disease, understand your options

If your urologist says you have Peyronie's disease with a curvature of 30 degrees or more and a plaque that can be felt, ask:

  • Is XIAFLEX® right for me?
  • What is involved in treatment with XIAFLEX®?
  • Are you trained to administer XIAFLEX®? If not, can you refer me to someone who is?
  • Are there other FDA-approved treatments for Peyronie's disease?
  • What are the possible side effects with each treatment option?

Download a helpful guide you can use when
talking with your HCP

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Important Safety Information
for XIAFLEX®

Do not receive XIAFLEX® if you:
  • have been told by your healthcare provider that the Peyronie's plaque to be treated involves the "tube" that your urine passes through (urethra)
  • are allergic to collagenase clostridium histolyticum or any of the ingredients in XIAFLEX®, or to any other collagenase product. See the end of the Medication Guide for a complete list of ingredients in XIAFLEX®

XIAFLEX® can cause serious side effects, including:

  1. Penile fracture (corporal rupture) or other serious injury to the penis. Receiving an injection of XIAFLEX® may cause damage to the tubes in your penis called the corpora. After treatment with XIAFLEX®, one of these tubes may break during an erection. This is called a corporal rupture or penile fracture. This could require surgery to fix the damaged area. Damage to your penis might not get better after a corporal rupture.
    • After treatment with XIAFLEX®, blood vessels in your penis may also break, causing blood to collect under the skin (hematoma). This could require a procedure to drain the blood from under the skin

    Symptoms of corporal rupture or other serious injury to your penis may include:

    • a popping sound or sensation in an erect penis
    • sudden loss of the ability to maintain an erection
    • pain in your penis
    • purple bruising and swelling of your penis
    • difficulty urinating or blood in the urine

    Call your healthcare provider right away if you have any of the symptoms of corporal rupture or serious injury to the penis listed above.

    Do not have sex or any other sexual activity between the first and second injections of a treatment cycle.

    Do not have sex or have any other sexual activity for at least 4 weeks after the second injection of a treatment cycle with XIAFLEX® and after any pain and swelling has gone away.

    XIAFLEX® for the treatment of Peyronie's disease is only available through a restricted program called the XIAFLEX® Risk Evaluation and Mitigation Strategy (REMS) Program. For more information about the XIAFLEX® REMS Program, go to www.XIAFLEXREMS.com or call 1‑877‑942‑3539.

  2. Hypersensitivity reactions, including anaphylaxis. Severe allergic reactions can happen in people who receive XIAFLEX®, because it contains foreign proteins.

    Call your healthcare provider right away if you have any of these symptoms of an allergic reaction after an injection of XIAFLEX®:

    • hives
    • swollen face
    • breathing trouble
    • chest pain
    • low blood pressure
    • dizziness or fainting

Before receiving XIAFLEX®, tell your healthcare provider if you have had an allergic reaction to a previous XIAFLEX® injection, or have a bleeding problem or any other medical conditions. Tell your healthcare provider about all the medicines you take, including prescription and non‑prescription medicines, vitamins, and herbal supplements. Using XIAFLEX® with certain other medicines can cause serious side effects. Especially tell your healthcare provider if you take medicines to thin your blood (anticoagulants). If you are told to stop taking a blood thinner before your XIAFLEX® injection, your healthcare provider should tell you when to restart the blood thinner. Ask your healthcare provider or pharmacist for a list of these medicines if you are unsure.

What should I avoid while receiving XIAFLEX®?
Avoid situations that may cause you to strain your stomach (abdominal) muscles, such as straining during bowel movements.

Do not use a vacuum erection device during your treatment with XIAFLEX®.

XIAFLEX® can cause serious side effects, including increased chance of bleeding. Bleeding or bruising at the injection site can happen in people who receive XIAFLEX®. Talk to your healthcare provider if you have a problem with your blood clotting. XIAFLEX® may not be right for you.

The most common side effects with XIAFLEX® for the treatment of Peyronie's disease include:

  • a small collection of blood under the skin at the injection site (hematoma)
  • swelling at the injection site or along your penis
  • pain or tenderness at the injection site, along your penis and above your penis
  • penis bruising
  • itching of your penis or scrotum (genitals)
  • painful erection
  • erection problems (erectile dysfunction)
  • changes in the color of the skin of your penis
  • blisters at the injection site
  • pain with sex
  • a lump at the injection site (nodule)

Tell your healthcare provider if you have any side effect that bothers you or does not go away.

These are not all of the possible side effects with XIAFLEX®. For more information, ask your healthcare provider or pharmacist.

What is XIAFLEX®?

XIAFLEX® is a prescription medicine used to treat adult men with Peyronie's disease who have a "plaque" that can be felt and a curve in their penis greater than 30 degrees when treatment is started.

It is not known if XIAFLEX® is safe and effective in children under the age of 18.

Please see the full Prescribing Information, including Boxed Warning and Medication Guide.