For adult men with Peyronie’s disease who have a “plaque” that can be felt and a curve in their penis greater than 30 degrees when treatment is started

RESULTS WITH XIAFLEX

Proven to help reduce erectile curvature*

When paired with daily gentle stretching and straightening of the penis, XIAFLEX is proven to help gradually reduce erectile curvature due to Peyronie’s disease (PD).*

Average change in erectile curvature (treatment difference):

  • 17% in Study 1* and 11% in Study 2*

*Individual results may vary.

Results from 2 identical clinical trials evaluating how XIAFLEX works

Over an 18-week period, one group of 401 men received XIAFLEX injections and the other group of 211 men received placebo (no medicine) injections. Each treatment group received up to 4 treatment cycles and did gentle penile stretching and straightening activities. They were then observed without receiving any treatments for up to 52 weeks to:

  • Measure the percent change in erectile curvature from the beginning of the study
  • Measure the change in the self-reported Bother domain score from the beginning of the study
  • Evaluate the safety of using XIAFLEX

Improvement in erectile curvature

Men who received XIAFLEX and performed daily gentle penile stretching and straightening activities had an average change in their erectile curvature with a treatment difference of 17% in Study 1 and 11% in Study 2 from the beginning of the studies to Week 52, compared to men who were treated with placebo (no medicine).

Average erectile curve reduction (treatment difference):

  • 17%in Study 1*
  • &
  • 11%in Study 2*
*Individual results may vary.

Before

A depiction of a 30° degree erectile curvature

After

A depiction of a 25° degree erectile curvature

Improvement in Bother score

The Bother domain score was measured at the beginning and end (52 weeks) of the studies. The Bother domain score is a total score from answers about the following items:

  • Concern about how their erection looks and about erection pain
  • Impact of PD on frequency of intercourse
  • Impact of PD on intercourse

Men who received XIAFLEX reported improvement in Bother score from the beginning of the study to Week 52 compared to placebo.

A middle aged couple where the man is smiling at the camera and the woman is smiling supportively at the manActor portrayals.

XIAFLEX was not associated with shortening of penile length in clinical trials in the treatment of PD.

XIAFLEX can cause serious side effects including: penile fracture (corporal rupture) or other serious injury to the penis; hypersensitivity reactions, including anaphylaxis; back pain reactions; or fainting. See Important Safety Information below.

An icon of an orange and white map marker

Find a Urology Specialist

Find a Urology Specialist trained to use XIAFLEX near you who can check your symptoms and diagnose PD.

Search Now
Actor portrayals of a doctor consulting with a Peyronie’s disease patientActor portrayals.

Why real patients chose XIAFLEX

“I’ve finished my treatment with XIAFLEX and I’m very happy with the result.”

– Del, actual patient

Meet Del who, with the help of his wife, found a Urology Specialist who diagnosed and successfully treated Del’s PD with XIAFLEX. Individual results may vary.

A white check mark in an orange circle
Benefits of XIAFLEX

Discover how XIAFLEX may help reduce the bend.

Icon of a white wallet with an orange dot
Paying for XIAFLEX

Eligible patients may qualify for copay assistance.†

  1. By accepting this offer, you agree to report the value received under this offer to any health insurer or other third party paying for any part of the XIAFLEX prescription if you are required to do so by benefit terms, contract, or law.
  2. This offer is not valid for prescriptions reimbursed in whole or in part by Medicare, Medicare Prescription Drug Benefit plans, Medicare Advantage, VA, Medicaid, or similar federal or state programs, or where otherwise prohibited by law.
  3. By accepting this offer, you agree that Endo USA, Inc. or those working on its behalf may contact your doctor to verify information about treatment that is relevant to verifying your eligibility for this offer.
  4. This offer is only valid for doses of XIAFLEX administered in the US.
  5. This offer is valid for the out-of-pocket cost for the dose of XIAFLEX only. Offer is not valid for any other products or other out-of-pocket costs (for example, office visit charges, office visit copays, or injection/administration costs), even if those costs are associated with the administration of a dose of XIAFLEX.
  6. This offer is valid only if you have not used this program within the last 30 days.
  7. The selling, purchasing, trading, or counterfeiting of this offer is prohibited.
  8. Endo USA, Inc. reserves the right to rescind, revoke, or amend this offer without notice.
  9. By participating, you understand and agree to comply with the terms and conditions of this offer as set forth above.

Important Safety Information

Do not receive XIAFLEX if:

  • the Peyronie’s plaque to be treated involves the “tube” that your urine passes through (urethra).
  • you are allergic to collagenase clostridium histolyticum or any of the ingredients in XIAFLEX, or to any other collagenase product. See the end of the Medication Guide for a complete list of ingredients in XIAFLEX.

XIAFLEX can cause serious side effects, including:

  • Penile fracture (corporal rupture) or other serious injury to the penis. Receiving an injection of XIAFLEX may cause damage to the tubes in your penis called the corpora. After treatment with XIAFLEX, one of these tubes may break during an erection. This is called a corporal rupture or penile fracture. This could require surgery to fix the damaged area. Damage to your penis might not get better after a corporal rupture.
    • After treatment with XIAFLEX, blood vessels in your penis may also break, causing blood to collect under the skin (hematoma). This could require a procedure to drain the blood from under the skin. If a hematoma appears, skin and soft tissue necrosis (death of skin cells) may develop in that area, which could require surgery.

    Symptoms of corporal rupture or other serious injury to your penis may include:

    • a popping sound or sensation in an erect penis
    • sudden loss of the ability to maintain an erection
    • pain in your penis
    • purple bruising and swelling of your penis
    • difficulty urinating or blood in the urine

Call your healthcare provider right away if you have any of the symptoms of corporal rupture or serious injury to the penis listed above.

Do not have sex or any other sexual activity between the first and second injections of a treatment cycle.

Do not have sex or have any other sexual activity for at least 4 weeks after the second injection of a treatment cycle with XIAFLEX and after any pain and swelling has gone away.

XIAFLEX for the treatment of Peyronie’s disease is only available through a restricted program called the XIAFLEX Risk Evaluation and Mitigation Strategy (REMS) Program.

  • Hypersensitivity reactions, including anaphylaxis. Severe allergic reactions can happen in people who receive XIAFLEX, because it contains foreign proteins.

    Call your healthcare provider right away if you have any of these symptoms of an allergic reaction after an injection of XIAFLEX:

    • hives
    • swollen face
    • breathing trouble
    • chest pain
    • low blood pressure
    • dizziness or fainting

  • Back pain reactions. After receiving an injection of XIAFLEX for Peyronie’s disease, you may suddenly feel back pain, including severe lower back pain moving to your legs, feet, chest and arms. The back pain may also include spasms and make it hard to walk. These symptoms usually go away in 15 minutes or less, but may last longer.

    Tell your healthcare provider right away if you have sudden back pain, chest pain, or hard time walking after an injection.

  • Fainting. Fainting (passing out) or near fainting can happen in men who receive XIAFLEX, especially if they have severe penile pain.

    If you have dizziness or feel faint after receiving XIAFLEX, lie down until the symptoms go away.

Before receiving XIAFLEX, tell your healthcare provider if you have had an allergic reaction to a previous XIAFLEX injection, have a bleeding problem, received XIAFLEX for another condition, or any other medical conditions. Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Using XIAFLEX with certain other medicines can cause serious side effects. Especially tell your healthcare provider if you take medicines to thin your blood (anticoagulants). If you are told to stop taking a blood thinner before your XIAFLEX injection, your healthcare provider should tell you when to restart the blood thinner. Ask your healthcare provider or pharmacist for a list of these medicines, if you are not sure.

What should I avoid while receiving XIAFLEX?

Avoid situations that may cause you to strain your stomach (abdominal) muscles, such as straining during bowel movements.

Do not use a vacuum erection device during your treatment with XIAFLEX.

XIAFLEX can cause serious side effects, including increased chance of bleeding. Bleeding or bruising at the injection site can happen in people who receive XIAFLEX. Talk to your healthcare provider if you have a problem with your blood clotting. XIAFLEX may not be right for you.

The most common side effects with XIAFLEX for the treatment of Peyronie’s disease include:

  • a small collection of blood under the skin at the injection site (hematoma)
  • swelling at the injection site or along your penis
  • pain or tenderness at the injection site, along your penis and above your penis
  • penis bruising
  • itching of your penis or scrotum (genitals)
  • painful erection
  • erection problems (erectile dysfunction)
  • changes in the color of the skin of your penis
  • blisters at the injection site
  • pain with sex
  • a lump at the injection site (nodule)

Tell your healthcare provider if you have any side effect that bothers you or does not go away.

These are not all of the possible side effects with XIAFLEX. For more information, ask your healthcare provider or pharmacist. You may report side effects to FDA at 1-800-FDA-1088.