Prepare for the discussion.
Feel prepared to talk to your Urology Specialist about PD and XIAFLEX.
For adult men with Peyronie’s disease who have a “plaque” that can be felt and a curve in their penis greater than 30 degrees when treatment is started
*Endo USA, Inc. maintains a list of physicians who have received the necessary Risk Evaluation and Mitigation Strategy (REMS) training and have experience in injecting XIAFLEX 20 or more injections over a 12-month period as designated by an orange check mark.
Physicians who have received the necessary REMS training, but have not administered at least 20 injections of XIAFLEX over a 12-month period, are also listed on this website, unless they have administered <1 injection within the last 12 months, in which case they will not be listed. This XIAFLEX usage information will be updated on an annual basis.
Physicians listed on this website are not affiliated with Endo USA, Inc. and do not pay to be on this list or to be designated as experienced users of XIAFLEX.
The Specialist Locator is a directory of physicians who have notified Endo USA, Inc. that they are experienced in injection procedures of the penis and in the treatment of Peyronie’s disease. Inclusion of a physician in the Specialist Locator does not constitute a referral, recommendation, endorsement, or verification of credentials, qualifications, or abilities of the physician listed. Conversely, the absence of a physician’s name and information should not be construed as a negative comment from Endo USA, Inc. about the physician’s credentials, qualifications, or abilities.
Endo shall not be liable for any harm resulting from your reliance on information contained in the Specialist Locator.
Feel prepared to talk to your Urology Specialist about PD and XIAFLEX.
What you pay for XIAFLEX depends on your health benefits or insurance coverage.
†Most eligible patients with commercial insurance plans should pay a $0 copay for XIAFLEX. Predictions based on historical analysis of claims filed September 2022 through August 2023.
Do not receive XIAFLEX if:
XIAFLEX can cause serious side effects, including:
Symptoms of corporal rupture or other serious injury to your penis may include:
Call your healthcare provider right away if you have any of the symptoms of corporal rupture or serious injury to the penis listed above.
Do not have sex or any other sexual activity between the first and second injections of a treatment cycle.
Do not have sex or have any other sexual activity for at least 4 weeks after the second injection of a treatment cycle with XIAFLEX and after any pain and swelling has gone away.
XIAFLEX for the treatment of Peyronie’s disease is only available through a restricted program called the XIAFLEX Risk Evaluation and Mitigation Strategy (REMS) Program.
Hypersensitivity reactions, including anaphylaxis. Severe allergic reactions can happen in people who receive XIAFLEX, because it contains foreign proteins.
Call your healthcare provider right away if you have any of these symptoms of an allergic reaction after an injection of XIAFLEX:
Back pain reactions. After receiving an injection of XIAFLEX for Peyronie’s disease, you may suddenly feel back pain, including severe lower back pain moving to your legs, feet, chest and arms. The back pain may also include spasms and make it hard to walk. These symptoms usually go away in 15 minutes or less, but may last longer.
Tell your healthcare provider right away if you have sudden back pain, chest pain, or hard time walking after an injection.
Fainting. Fainting (passing out) or near fainting can happen in men who receive XIAFLEX, especially if they have severe penile pain.
If you have dizziness or feel faint after receiving XIAFLEX, lie down until the symptoms go away.
Before receiving XIAFLEX, tell your healthcare provider if you have had an allergic reaction to a previous XIAFLEX injection, have a bleeding problem, received XIAFLEX for another condition, or any other medical conditions. Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Using XIAFLEX with certain other medicines can cause serious side effects. Especially tell your healthcare provider if you take medicines to thin your blood (anticoagulants). If you are told to stop taking a blood thinner before your XIAFLEX injection, your healthcare provider should tell you when to restart the blood thinner. Ask your healthcare provider or pharmacist for a list of these medicines, if you are not sure.
What should I avoid while receiving XIAFLEX?
Avoid situations that may cause you to strain your stomach (abdominal) muscles, such as straining during bowel movements.
Do not use a vacuum erection device during your treatment with XIAFLEX.
XIAFLEX can cause serious side effects, including increased chance of bleeding. Bleeding or bruising at the injection site can happen in people who receive XIAFLEX. Talk to your healthcare provider if you have a problem with your blood clotting. XIAFLEX may not be right for you.
The most common side effects with XIAFLEX for the treatment of Peyronie’s disease include:
Tell your healthcare provider if you have any side effect that bothers you or does not go away.
These are not all of the possible side effects with XIAFLEX. For more information, ask your healthcare provider or pharmacist. You may report side effects to FDA at 1-800-FDA-1088.