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A prescription medicine used to treat adult men with Peyronie's disease who have a "plaque" that can be felt and a curve in their penis greater than 30 degrees when treatment is started

It can be hard to talk about Peyronie's disease. Locate specialists nearest you who may be able to help and determine if XIAFLEX® is right for you.

Take the first step

Find specialists nearest you who treat with XIAFLEX®

Enter your ZIP Code in the search tool below to find specialists* in your area who are trained in administering XIAFLEX®.

*Endo Pharmaceuticals Inc. maintains a list of physicians who have received the necessary Risk Evaluation and Mitigation Strategy (REMS) training and have experience in injecting XIAFLEX® 20 or more injections over the last 12 months as designated by a blue check mark. This XIAFLEX® usage information will be updated on a rolling monthly basis.

Physicians who have received the necessary REMS training, but have not administered at least 20 injections/vials of XIAFLEX® over this time frame, are also listed on this website, unless they have administered <1 injection/vial, within the last 6 months, in which case they will not be listed.

Physicians listed on this website are not affiliated with Endo Pharmaceuticals Inc., and do not pay to be on this list or to be designated as experienced users of XIAFLEX®.

The Specialist Locator is a directory of physicians who have notified Endo Pharmaceuticals Inc. that (1) they are experienced in injection procedures of the penis and in the treatment of Peyronie's disease and (2) they wish to be included in this directory. Inclusion of a physician in the Specialist Locator does not constitute a referral, recommendation, endorsement, or verification of credentials, qualifications, or abilities of the physician listed. Conversely, the absence of a physician's name and information should not be construed as a negative comment from Endo Pharmaceuticals Inc. about the physician's credentials, qualifications, or abilities.

Endo Pharmaceuticals shall not be liable for any harm resulting from your reliance on information contained in the Specialist Locator.

Important Safety Information for XIAFLEX®

Do not receive XIAFLEX® if you:
  • have been told by your healthcare provider that the Peyronie's plaque to be treated involves the "tube" that your urine passes through (urethra)
  • are allergic to collagenase clostridium histolyticum or any of the ingredients in XIAFLEX®, or to any other collagenase product. See the end of the Medication Guide for a complete list of ingredients in XIAFLEX®

XIAFLEX® can cause serious side effects, including:

  1. Penile fracture (corporal rupture) or other serious injury to the penis. Receiving an injection of XIAFLEX® may cause damage to the tubes in your penis called the corpora. After treatment with XIAFLEX®, one of these tubes may break during an erection. This is called a corporal rupture or penile fracture. This could require surgery to fix the damaged area. Damage to your penis might not get better after a corporal rupture.
    • After treatment with XIAFLEX®, blood vessels in your penis may also break, causing blood to collect under the skin (hematoma). This could require a procedure to drain the blood from under the skin

    Symptoms of corporal rupture or other serious injury to your penis may include:

    • a popping sound or sensation in an erect penis
    • sudden loss of the ability to maintain an erection
    • pain in your penis
    • purple bruising and swelling of your penis
    • difficulty urinating or blood in the urine

    Call your healthcare provider right away if you have any of the symptoms of corporal rupture or serious injury to the penis listed above.

    Do not have sex or any other sexual activity between the first and second injections of a treatment cycle.

    Do not have sex or have any other sexual activity for at least 2 weeks after the second injection of a treatment cycle with XIAFLEX® and after any pain and swelling has gone away.

    XIAFLEX® for the treatment of Peyronie's disease is only available through a restricted program called the XIAFLEX® Risk Evaluation and Mitigation Strategy (REMS) Program. For more information about the XIAFLEX® REMS Program, go to www.XIAFLEXREMS.com or call 1‑877‑942‑3539.

  2. Hypersensitivity reactions, including anaphylaxis. Severe allergic reactions can happen in people who receive XIAFLEX®, because it contains foreign proteins.

    Call your healthcare provider right away if you have any of these symptoms of an allergic reaction after an injection of XIAFLEX®:

    • hives
    • swollen face
    • breathing trouble
    • chest pain
    • low blood pressure
    • dizziness or fainting

Before receiving XIAFLEX®, tell your healthcare provider if you have had an allergic reaction to a previous XIAFLEX® injection, or have a bleeding problem or any other medical conditions. Tell your healthcare provider about all the medicines you take, including prescription and non‑prescription medicines, vitamins, and herbal supplements. Using XIAFLEX® with certain other medicines can cause serious side effects. Especially tell your healthcare provider if you take medicines to thin your blood (anticoagulants). If you are told to stop taking a blood thinner before your XIAFLEX® injection, your healthcare provider should tell you when to restart the blood thinner. Ask your healthcare provider or pharmacist for a list of these medicines if you are unsure.

XIAFLEX® can cause serious side effects, including increased chance of bleeding. Bleeding or bruising at the injection site can happen in people who receive XIAFLEX®. Talk to your healthcare provider if you have a problem with your blood clotting. XIAFLEX® may not be right for you.

The most common side effects with XIAFLEX® for the treatment of Peyronie's disease include:

  • a small collection of blood under the skin at the injection site (hematoma)
  • swelling at the injection site or along your penis
  • pain or tenderness at the injection site, along your penis and above your penis
  • penis bruising
  • itching of your penis or scrotum (genitals)
  • painful erection
  • erection problems (erectile dysfunction)
  • changes in the color of the skin of your penis
  • blisters at the injection site
  • pain with sex
  • a lump at the injection site (nodule)

Tell your healthcare provider if you have any side effect that bothers you or does not go away.

These are not all of the possible side effects with XIAFLEX®. For more information, ask your healthcare provider or pharmacist.

What is XIAFLEX®?

XIAFLEX® is a prescription medicine used to treat adult men with Peyronie's disease who have a "plaque" that can be felt and a curve in their penis greater than 30 degrees when treatment is started.

It is not known if XIAFLEX® is safe and effective in children under the age of 18.

Please see the full Prescribing Information, including Boxed Warning and Medication Guide.