A prescription medicine used to treat adult men with Peyronie’s disease who have a “plaque” that can be felt and a curve in their penis greater than 30 degrees when treatment is started
A prescription medicine used to treat adult men with Peyronie’s disease who have a “plaque” that can be felt and a curve in their penis greater than 30 degrees when treatment is started

Find out about Peyronie’s disease treatment

Nonsurgical and surgical treatment options are available to help with your curved erection

If your healthcare professional (HCP) diagnoses you with Peyronie's disease, he or she may talk with you about different treatment options. Sometimes, an HCP may advise you to hold off on treatment and wait to see if your curve gets any worse.

As you consider treatment options, keep in mind that Peyronie's disease is unlikely to go away on its own and may get worse over time.

A urologist can help you decide which treatment option is right for you and discuss the benefits and risks of each one.

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Nonsurgical treatment for Peyronie’s disease

There is only 1 nonsurgical treatment option for appropriate patients with Peyronie's disease approved by the Food and Drug Administration (FDA).

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XIAFLEX® (collagenase clostridium histolyticum)

  • For adult men with Peyronie’s disease who have these 2 symptoms when treatment is started: a Peyronie's plaque (a bump of scar tissue under the skin of the penis) that can be felt and a curved erection bent at least 30 degrees
  • A series of in-office, enzyme injections into the Peyronie's plaque that's causing your curved erection
  • The enzymes work to help break down the plaque
  • You and your HCP will also do gentle stretching and straightening activities to help reduce the curve in your erection and straighten the shaft of your penis

There are other injectable treatments, oral and topical medicines, and medical therapies your HCP may suggest for your curved erection. None of these are approved by the FDA to treat Peyronie's disease.

Surgical treatment for Peyronie’s disease

There are also surgical procedures that may help reduce erectile curvature. These procedures involve cutting open the penis in a hospital.

As with any treatment for Peyronie’s disease, please discuss the benefits and risks of surgical options with a urologist.

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Plication

  • Tissue inside of the penis is removed or pinched together on the opposite side of the penis bend to help straighten the erectile curvature
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Grafting

  • The scar tissue that makes up the plaque is cut or partially removed
  • Scarred penile tissue is then replaced or expanded with healthy tissue (called grafts)
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Implants

  • A bendable or inflatable cylinder device is permanently inserted inside of the penis to help correct erectile curvature
  • Men who get implants can only have an erection by using this device
  • If the implant doesn't help straighten the penis on its own, this procedure may be combined with one of the other surgeries described

Get the conversation started

with a urologist about getting diagnosed and treated for Peyronie’s disease.

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A urologist can help you get diagnosed and treated for Peyronie's disease

Urologists are doctors who specialize in the treatment of men's urological and sexual health conditions, like Peyronie's disease.

Even if you see a primary care provider first, you may need to talk to a urologist to get diagnosed and treated for this type of condition.

It may comfort you to know that urologists are used to discussing these kinds of things and are familiar with this condition, which could be Peyronie’s disease. They talk about sensitive subjects like this all of the time.

Find a urologist to get diagnosed

Getting diagnosed

Get the conversation started to find out if you have Peyronie’s disease.

Ask your urologist:

  • Is my curved erection Peyronie's disease?
  • Is my curve 30 degrees or more?
  • Do I have a bump (a plaque) that can be felt?

Be sure to also talk about any other issues or symptoms that may bother you about your curved erection.

Getting treated

If your urologist says you have Peyronie's disease with a plaque that can be felt and a curve in your penis of at least 30 degrees, you may be a good candidate for nonsurgical treatment with XIAFLEX®.

Ask your urologist:

  • Is nonsurgical treatment with XIAFLEX® right for me?
  • What's involved in treatment with XIAFLEX®?
  • Do you have experience injecting XIAFLEX®? If not, can you refer me to someone who does?
  • Are there other FDA-approved treatments for Peyronie's disease?
  • What are the possible side effects with each treatment option?
Get the facts about nonsurgical treatment with XIAFLEX®
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Important Safety Information for XIAFLEX® (collagenase clostridium histolyticum)

Do not receive XIAFLEX® if you:

  • have been told by your healthcare provider that the Peyronie's plaque to be treated involves the "tube" that your urine passes through (urethra);
  • are allergic to collagenase clostridium histolyticum or any of the ingredients in XIAFLEX®, or to any other collagenase product. See the end of the Medication Guide for a complete list of ingredients in XIAFLEX®.

XIAFLEX® can cause serious side effects, including:

  1. Penile fracture (corporal rupture) or other serious injury to the penis. Receiving an injection of XIAFLEX® may cause damage to the tubes in your penis called the corpora. After treatment with XIAFLEX®, one of these tubes may break during an erection. This is called a corporal rupture or penile fracture. This could require surgery to fix the damaged area. Damage to your penis might not get better after a corporal rupture.
    • After treatment with XIAFLEX®, blood vessels in your penis may also break, causing blood to collect under the skin (hematoma). This could require a procedure to drain the blood from under the skin

    Symptoms of corporal rupture or other serious injury to your penis may include:

    • a popping sound or sensation in an erect penis
    • sudden loss of the ability to maintain an erection
    • pain in your penis
    • purple bruising and swelling of your penis
    • difficulty urinating or blood in the urine

    Call your healthcare provider right away if you have any of the symptoms of corporal rupture or serious injury to the penis listed above.

    Do not have sex or any other sexual activity between the first and second injections of a treatment cycle.

    Do not have sex or have any other sexual activity for at least 4 weeks after the second injection of a treatment cycle with XIAFLEX® and after any pain and swelling have gone away.

    XIAFLEX® for the treatment of Peyronie's disease is only available through a restricted program called the XIAFLEX® Risk Evaluation and Mitigation Strategy (REMS) Program. For more information about the XIAFLEX® REMS Program, go to www.XIAFLEXREMS.com or call 1‑877‑313‑1235.

  2. Hypersensitivity reactions, including anaphylaxis. Severe allergic reactions can happen in people who receive XIAFLEX®, because it contains foreign proteins.

    Call your healthcare provider right away if you have any of these symptoms of an allergic reaction after an injection of XIAFLEX®:

    • hives
    • swollen face
    • breathing trouble
    • chest pain
    • low blood pressure
    • dizziness or fainting

Before receiving XIAFLEX®, tell your healthcare provider if you have had an allergic reaction to a previous XIAFLEX® injection, or have a bleeding problem or any other medical conditions. Tell your healthcare provider about all the medicines you take, including prescription and non‑prescription medicines, vitamins, and herbal supplements. Using XIAFLEX® with certain other medicines can cause serious side effects. Especially tell your healthcare provider if you take medicines to thin your blood (anticoagulants). If you are told to stop taking a blood thinner before your XIAFLEX® injection, your healthcare provider should tell you when to restart the blood thinner. Ask your healthcare provider or pharmacist for a list of these medicines if you are unsure.

What should I avoid while receiving XIAFLEX®?
Avoid situations that may cause you to strain your stomach (abdominal) muscles, such as straining during bowel movements.

Do not use a vacuum erection device during your treatment with XIAFLEX®.

XIAFLEX® can cause serious side effects, including increased chance of bleeding. Bleeding or bruising at the injection site can happen in people who receive XIAFLEX®. Talk to your healthcare provider if you have a problem with your blood clotting. XIAFLEX® may not be right for you.

The most common side effects with XIAFLEX® for the treatment of Peyronie's disease include:

  • a small collection of blood under the skin at the injection site (hematoma)
  • swelling at the injection site or along your penis
  • pain or tenderness at the injection site, along your penis and above your penis
  • penis bruising
  • itching of your penis or scrotum (genitals)
  • painful erection
  • erection problems (erectile dysfunction)
  • changes in the color of the skin of your penis
  • blisters at the injection site
  • pain with sex
  • a lump at the injection site (nodule)

Tell your healthcare provider if you have any side effect that bothers you or does not go away.

These are not all of the possible side effects with XIAFLEX®. For more information, ask your healthcare provider or pharmacist.

What is XIAFLEX®?

XIAFLEX® is a prescription medicine used to treat adult men with Peyronie's disease who have a "plaque" that can be felt and a curve in their penis greater than 30 degrees when treatment is started.

It is not known if XIAFLEX® is safe and effective in children under the age of 18.

Please see the full Prescribing Information, including Boxed Warning and Medication Guide.